| 货号 | 5042S |
| 反应种属 | Human/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | SGLT1 Antibody detects endogenous levels of total SGLT1 protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Sodium/glucose cotransporter 1 (SGLT1) is an active glucose transporter, which utilizes sodium gradients to transport glucose into cells independent of extracellular glucose concentration. SGLT1 is an essential glucose active transport protein that helps maintain high intracellular glucose levels (1). Expression of SGLT1 is mainly seen in intestinal and kidney epithelial cells, although a recent study also characterized SGLT1 expression in cardiac myocytes (2). Abnormal SGLT1 expression may be associated with cases of type 2 diabetes mellitus and myocardial ischaemia (2). Mutation of the corresponding SGLT1 gene can result in congenital glucose/galactose malabsorption, which can lead to neonatal diarrhea and subsequent death if left untreated (3). A recent study of the role of EGFR in cancer cell survival indicates that EGFR can prevent autophagic cell death independent of EGFR kinase activity because the receptor interacts with and stabilizes SLGT1 to maintain basal intracellular glucose levels (4). |
| 存放说明 | -20C |
| 计算分子量 | 61 |
| 参考文献 | 1 . Wright, E.M. et al. (1994) J Exp Biol 196, 197-212. 2 . Banerjee, S.K. et al. (2009) Cardiovasc Res 84, 111-8. 3 . Martín, M.G. et al. (1996) Nat Genet 12, 216-20. 4 . Weihua, Z. et al. (2008) Cancer Cell 13, 385-93. |
Western blot analysis of extracts from Hep G2 and 293T cells using SGLT1 Antibody. Wetern blot检测Hep G2 and 293T细胞系提取物，所用抗体为SGLT1 Antibody。 |
