| 货号 | 5595S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | SGK2 Antibody detects endogenous levels of total SGK2 protein。 |
| 使用方法 | WB(1:1000) IP (1:100) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Serum and glucocorticoid-inducible kinase (SGK) is a serine/threonine kinase closely related to Akt (1). SGK is rapidly induced in response to a variety of stimuli, including serum, glucocorticoid, follicle stimulating hormone, osmotic shock, and mineralocorticoids. SGK activation can be accomplished via HGF PI3K-dependent pathways and by integrin-mediated PI3K-independent pathways (2,3). Induction and activation of SGK has been implicated in activating the modulation of anti-apoptotic and cell cycle regulation (4-6). SGK also plays an important role in activating certain potassium, sodium, and chloride channels, suggesting its involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion (2). SGK is negatively regulated by ubiquitination and proteasome degradation (7). |
| 存放说明 | -20C |
| 计算分子量 | 42 |
| 参考文献 | 1 . Webster, M.K. et al. (1993) Mol Cell Biol 13, 2031-40. 2 . Kobayashi, T. and Cohen, P. (1999) Biochem J 339 ( Pt 2), 319-28. 3 . Park, J. et al. (1999) EMBO J 18, 3024-33. 4 . Brunet, A. et al. (2001) Mol Cell Biol 21, 952-65. 5 . Mikosz, C.A. et al. (2001) J Biol Chem 276, 16649-54. 6 . Hayashi, M. et al. (2001) J Biol Chem 276, 8631-4. 7 . Brickley, D.R. et al. (2002) J Biol Chem 277, 43064-70. |
Western blot analysis of extracts from COS-7 cells, untransfected (-) or transfected with human SGK2 (+), using SGK2 Antibody. Western blot分析COS-7 细胞提取物，未转染组（-）和采用人类SGK2 (+)转染组，所用抗体为SGK2 Antibody。 | |
Western blot analysis of extracts from human and mouse liver tissues using SGK2 Antibody. Western blot分析人类和小鼠肝脏组织的提取物，所用抗体为SGK2 Antibody。 |
