| 货号 | 13771S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Semaphorin 4B Antibody recognizes endogenous levels of total semaphorin 4B protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | The semaphorin family of proteins is involved in axon guidance, cell migration, angiogenesis, and immune response. Plexins and neuropilins bind with high affinity to semaphorins to mediate their functions. Semaphorins are divided into seven classes of secreted or membrane-bound proteins. Members of Class 4 semaphorins include 4A through 4G; semaphorin 4B is a membrane-associated protein (1,2). Semaphorin 4B binds to the CLCP1 receptor and regulates cell motility (3). Furthermore, semaphorin 4B, like many other semaphorins, has a PDZ domain-binding motif at the carboxy terminus that interacts with PSD95 and localizes to the post-synaptic membrane (4). |
| 存放说明 | -20C |
| 计算分子量 | 95 |
| 参考文献 | 1 . Pasterkamp, R.J. and Kolodkin, A.L. (2003) Curr Opin Neurobiol 13, 79-89. 2 . Kruger, R.P. et al. (2005) Nat Rev Mol Cell Biol 6, 789-800. 3 . Nagai, H. et al. (2007) Oncogene 26, 4025-31. 4 . Burkhardt, C. et al. (2005) FEBS Lett 579, 3821-8. |
Western Blot analysis of cell extracts from either wild-type or SEMA4B (-/-) mouse brain using Semaphorin 4B Antibody (upper) or α-Actinin (D6F6) XP® Rabbit mAb (lower). SEMA4B (-/-) mouse brain was provided by Dr. Oded Behar, Developmental Biology and Cancer Research, The Hebrew University of Jerusalem, Israel. |
