| 货号 | 3740S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | SDF1 Antibody detects recombinant SDF1 protein and is expected to recognize both SDF1α and SDF1β isoforms. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Recombinant |
| 背景 | The stromal cell derived factor 1 (SDF1, CXCL12) is a small, pro-inflammatory chemoattractant cytokine that regulates leukocyte trafficking through interactions with its cognate 7-transmembrane G protein-coupled receptors (1). The SDF1 receptor, CXCR4, also serves as a coreceptor for the entry of human immunodeficiency virus into target cells (2). SDF1 may regulate homing and maintenance of CXCR4-expressing stem or progenitor cells, including embryonic and many somatic stem cells (3,4). Many cancer cells express CXCR4, suggesting that SDF1 plays a role in cancer metastasis (5,6). Alternative splicing and differential processing during maturation produce a pair of SDF1 isoforms (SDF1α and SDF1β) that have different properties and biological activities (7). Additional isoforms of SDF1 have been reported (8,9). |
| 存放说明 | -20C |
| 计算分子量 | 9 |
| 参考文献 | 1 . Maekawa, T. and Ishii, T. (2000) Intern Med 39, 90-100. 2 . Ray, N. and Doms, R.W. (2006) Curr Top Microbiol Immunol 303, 97-120. 3 . Sugiyama, T. et al. (2006) Immunity 25, 977-88. 4 . Ara, T. et al. (2003) Immunity 19, 257-67. 5 . Kucia, M. et al. (2004) J Mol Histol 35, 233-45. 6 . Ratajczak, M.Z. et al. (2006) Leukemia 20, 1915-24. 7 . De La Luz Sierra, M. et al. (2004) Blood 103, 2452-9. 8 . Gleichmann, M. et al. (2000) Eur J Neurosci 12, 1857-66. 9 . Yu, L. et al. (2006) Gene 374, 174-9. |
Western blot analysis of recombinant human SDF1 protein using SDF1 Antibody.Western免疫印迹。用SDF1 Antibody研究重组的人SDF1 蛋白。 |
