| 货号 | 8446S |
| 反应种属 | Human/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | R-Ras Antibody recognizes endogenous levels of total R-Ras protein. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | R-Ras, a member of the small GTPase family, is homologous to H-, K- and N-Ras, but does not activate MAP kinase pathways and is only weakly oncogenic (1). Instead, R-Ras is engaged in integrin activation (2). The effector loop and the carboxy-terminal proline-rich and prenylation sites of R-Ras are critical for integrin activation (3,4). Phosphorylation by EphB2 receptor tyrosine kinase and Src at Tyr66 of R-Ras suppresses integrin activity (5,6). |
| 存放说明 | -20C |
| 计算分子量 | 24 |
| 参考文献 | 1 . Self, A. J. et al. (2001) J. Cell Sci. 114, 1357-1366. 2 . Zhang, Z. et al. (1996) Cell 85, 61-69. 3 . Oertli, B. et al. (2000) Oncogene 19, 4961-4969. 4 . Wang, B. et al. (2000) J Biol Chem 275, 5222-7. 5 . Zou, J.X. et al. (1999) Proc Natl Acad Sci U S A 96, 13813-8. 6 . Zou, J.X. et al. (2002) J Biol Chem 277, 1824-7. |
Western blot analysis of extracts from various cell lines using R-Ras Antibody. 使用R-Ras Antibody，免疫印迹（Western Blot）分析不同细胞中R-Ras蛋白水平。 |
