| 货号 | 2765S |
| 反应种属 | Human/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | Ribosomal Protein L13a Antibody detects endogenous levels of total ribosomal protein L13a. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Ribosomal protein L13a (RPL13a, 60S ribosomal protein L13a) is a member of the L13 ribosomal protein family and a structural component of the 60S ribosomal subunit (1). RPL13a appears to play an important role in transcript-specific translational silencing. Interferon-γ induces the phosphorylation of RPL13a and triggers the release of this protein from the 60S ribosomal subunit (2). Free RPL13a protein binds to the GAIT (interferon-γ-activated inhibitor of translation) complex at the 3-UTR of ceruloplasmin (Cp) mRNA to repress Cp expression (2). RPL13a bound to the GAIT complex interacts with eIF4G, which prevents the recruitment of 43S ribosomal subunit and results in transcript-specific translation suppression (3). |
| 存放说明 | -20C |
| 计算分子量 | 23 |
| 参考文献 | 1 . Higa, S. et al. (1999) Gene 240, 371-7. 2 . Mazumder, B. et al. (2003) Cell 115, 187-98. 3 . Kapasi, P. et al. (2007) Mol Cell 25, 113-26. |
Western blot analysis of extracts from various cell types using Ribosomal Protein L13a Antibody. 使用Ribosomal Protein L13a Antibody，免疫印迹（Western Blot）分析在不同细胞系中Ribosomal Protein L13a蛋白水平。 |
