| 货号 | 3220S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | Ret Antibody detects endogenous levels of total Ret protein. |
| 使用方法 | WB(1:1000) IP (1:25) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | The Ret proto-oncogene (c-Ret) is a receptor tyrosine kinase that functions as a multicompetent receptor complex in conjunction with other membrane-bound ligand-binding GDNF family receptors (1). Ligands that bind the Ret receptor include the glial cell line-derived neurotropic factor (GDNF) and its congeners neurturin, persephin and artemin (2-4). Alterations in the corresponding Ret gene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma and a congenital developmental disorder known as Hirschsprung’s disease (1,3). The Tyr905 residue located in the Ret kinase domain plays a crucial role in Ret catalytic and biological activity. Substitution of Phe for Tyr905 dramatically inhibits Ret autophosphorylation activity (5). |
| 存放说明 | -20C |
| 计算分子量 | 170, 175 |
| 参考文献 | 1 . Airaksinen, M.S. et al. (1999) Mol Cell Neurosci 13, 313-25. 2 . Takahashi, M. et al. (1989) Oncogene 4, 805-6. 3 . Manié, S. et al. (2001) Trends Genet 17, 580-9. 4 . Tallini, G. and Asa, S.L. (2001) Adv Anat Pathol 8, 345-54. 5 . Iwashita, T. et al. (1999) Oncogene 18, 3919-22. |
Western blot analysis of extracts from TT cells using Ret Antibody.用Ret Antibody对TT细胞的提取物进行免疫印记检测。 |
