| 货号 | 5250S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Renin Antibody detects transfected levels of human Renin protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Transfected Only |
| 背景 | Renin is a secreted proteinase whose enzymatic activity is to convert angiotensinogen into angiotensin I in the plasma, initiating a process that results in an elevation of blood pressure and increased sodium retention by the kidney (1). Renin is synthezed in kidney as a procursor, prorenin, which is released into circulation. Both renin and prorenin can bind to (pro)renin receptor and induce angiotensin-independent signaling events leading to activation of MAPKs and up-regulation of TGF-β1 and matrix proteins (2, 3). Defects in renin can cause renal tubular dysgenesis, a severe autosomal recessive disorder of renal tubular development (4, 5). |
| 存放说明 | -20C |
| 计算分子量 | 40-45 |
| 参考文献 | 1 . Castrop, H. et al. (2010) Physiol Rev 90, 607-73. 2 . Ichihara, A. et al. J Nephrol 22, 306-11. 3 . Nguyen, G. (2010) Ann Med 42, 13-8. 4 . Lacoste, M. et al. (2006) J Am Soc Nephrol 17, 2253-63. 5 . Gubler, M.C. and Antignac, C. (2010) Kidney Int 77, 400-6. |
Western blot analysis of extracts from COS-7 cells, mock transfected or transfected with a construct expression human Renin, using Renin Antibody.对未转染或转染了人Renin表达载体的COS-7细胞提取物，使用Renin抗体进行western blot分析。 |
