| 货号 | 5442S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | RBPSUH Antibody detects endogenous level of total RBPSUH protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | RBPSUH (Recombining binding protein suppressor of hairless) is the DNA-binding component of the transcription complex regulated by Notch signaling. In the absence of Notch activation, RBPSUH suppresses target gene expression through interactions with a co-repressor complex containing histone deacetylase. Upon activation, the Notch intracellular domain (NICD) enters the nucleus and binds to RBPSUH to displace the co-repressor complex and replace with a transcription activation complex including Maml, histone acetylase p300, leading to the transcription of Notch target genes (1-3). In addition, RBPSUH is also the DNA-binding partner for Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA2), a protein critical for latent viral transcription and immortalization of EBV-infected B cells (4,5). |
| 存放说明 | -20C |
| 计算分子量 | 61 |
| 参考文献 | 1 . Ehebauer, M. et al. (2006) Sci STKE 2006, cm7. 2 . Borggrefe, T. and Oswald, F. (2009) Cell Mol Life Sci 66, 1631-46. 3 . Kopan, R. and Ilagan, M.X. (2009) Cell 137, 216-33. 4 . Henkel, T. et al. (1994) Science 265, 92-5. 5 . Strobl, L.J. et al. (1997) Immunobiology 198, 299-306. |
Western blot analysis of extracts from various cells using RBPSUH Antibody.用RBPSUH抗体在western blot实验中检测多种细胞提取物。 |
