| 货号 | 2988S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | RANTES (P20) Antibody detects endogenous levels of total human RANTES protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | RANTES/CCL5 (regulated upon activation, T cell expressed and secreted) is a member of the "C-C" or β family of chemokines that induce inflammation and are associated with a number of inflammatory disorders (1,2). RANTES is produced and secreted mainly by CD8+ T cells, macrophages, and platelets, as well as epithelial cells, fibroblasts and some solid tumors (2-7). RANTES acts as a chemoattractant and has other regulatory functions on a number of cell types including monocytes, memory T cells, NK cells, eosinophils, basophils, dendritic cells, and mast cells (3, 7-9). Signaling by RANTES is mediated by several G-protein coupled receptors (GPCRs), including CCR1, CCR3, CCR4 and CCR5. |
| 存放说明 | -20C |
| 计算分子量 | 10 |
| 参考文献 | 1 . Schall, T.J. (1991) Cytokine 3, 165-83. 2 . Schall, T.J. et al. (1988) J Immunol 141, 1018-25. 3 . Kameyoshi, Y. et al. (1992) J Exp Med 176, 587-92. 4 . Rathanaswami, P. et al. (1993) J Biol Chem 268, 5834-9. 5 . Mattei, S. et al. (1994) Int J Cancer 56, 853-7. 6 . Stellato, C. et al. (1995) J Immunol 155, 410-8. 7 . Schall, T.J. et al. (1990) Nature 347, 669-71. 8 . Kuna, P. et al. (1992) J Immunol 149, 636-42. 9 . Mattoli, S. et al. (1995) Biochem Biophys Res Commun 209, 316-21. |
Western blot analysis of HeLa cells, mock transfected or transfected with human RANTES construct, using RANTES (P20) Antibody.Western免疫印迹。用RANTES (P20) Antibody研究对照转染或者转染表达人RANTES质粒的HeLa细胞的细胞提取液。 | |
Western blot analysis of extracts from differentiated THP-1 cells, untreated or treated overnight with LPS, using RANTES (P20) Antibody.Western免疫印迹。用RANTES (P20) Antibody研究未经处理和经LPS处理过夜已经分化的THP-1细胞的细胞提取液。 |
