RANK Ligand (L300) Antibody【科瑞奥博】

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RANK Ligand (L300) Antibody

货号： 4816S 基本售价： 3360.0 元规格： -

产品信息

概述
货号	4816S
反应种属	Human
来源宿主	Rabbit
应用	W/IP
目标/特异性	RANK Ligand (L300) Antibody detects endogenous levels of RANK Ligand. The antibody is predicted to detect soluble RANK Ligand.
使用方法	WB(1:1000) IP (1:50)

性能
供应商	CST
灵敏度	Transfected Only
背景	RANK (receptor activator of NF-κB) is a member of the tumor necrosis factor (TNF) receptor subfamily that is activated by its ligand, RANKL (TRANCE/OPGL/ODF), to promote survival of dendritic cells and differentiation of osteoclasts (1-4). Although RANK is widely expressed, its cell surface expression may be more restricted to dendritic cells and foreskin fibroblasts (1). RANK contains a 383-amino acid intracellular domain that associates with specific members of the TRAF family to NF-κB and JNK activiation (1,5). RANKL/RANK signaling may also lead to survival signaling through activation of the Akt pathway and an upregulation of survival proteins, including Bcl-xL (2,6). RANK signaling has been implicated as a potential therapeutic to inhibit bone loss and arthritis (7,8).
存放说明	-20C
计算分子量	35-45
参考文献	1 . Anderson, D.M. et al. (1997) Nature 390, 175-9. 2 . Wong, B.R. et al. (1997) J Exp Med 186, 2075-80. 3 . Lacey, D.L. et al. (1998) Cell 93, 165-76. 4 . Yasuda, H. et al. (1998) Proc. Natl. Acad. Sci. USA 95, 3597-602. 5 . Darnay, B.G. et al. (1998) J Biol Chem 273, 20551-5. 6 . Wong, B.R. et al. (1999) Mol Cell 4, 1041-9. 7 . Walsh, M.C. and Choi, Y. Cytokine Growth Factor Rev. 14, 251-63. 8 . Nakashima, T. et al. (2003) Curr. Opin. Rheumatol. 15, 280-7. 9 . Fata, J. E. et al. (2000) Cell 103, 41-50. 10 . Wong, B.R. et al. (1997) J Biol Chem 272, 25190-4. 11 . Hofbauer, L.C. (1999) Eur J Endocrinol 141, 195-210. 12 . Theill, L.E. et al. (2002) Annu Rev Immunol 20, 795-823. 13 . Mizuno, A. et al. (1998) Biochem Biophys Res Commun 247, 610-5. 14 . Kong, Y.Y. et al. (1999) Nature 397, 315-23.

参考图片

Western blot analysis of extracts from COS-7 cells, untransfected (-) or transfected with a construct expressing RANK Ligand, using RANK Ligand (L300) Antibody.Western免疫印迹。用RANK Ligand (L300) Antibody研究未转染 (-) 或者转染表达RANK配体的质粒的COS-7 细胞的细胞提取液。