| 货号 | 4845S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | RANK Antibody detects endogenous levels of RANK protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | RANK (receptor activator of NF-κB) is a member of the tumor necrosis factor (TNF) receptor subfamily that is activated by its ligand, RANKL (TRANCE/OPGL/ODF), to promote survival of dendritic cells and differentiation of osteoclasts (1-4). Although RANK is widely expressed, its cell surface expression may be more restricted to dendritic cells and foreskin fibroblasts (1). RANK contains a 383-amino acid intracellular domain that associates with specific members of the TRAF family to NF-κB and JNK activiation (1,5). RANKL/RANK signaling may also lead to survival signaling through activation of the Akt pathway and an upregulation of survival proteins, including Bcl-xL (2,6). RANK signaling has been implicated as a potential therapeutic to inhibit bone loss and arthritis (7,8). |
| 存放说明 | -20C |
| 计算分子量 | 80 |
| 参考文献 | 1 . Anderson, D.M. et al. (1997) Nature 390, 175-9. 2 . Wong, B.R. et al. (1997) J Exp Med 186, 2075-80. 3 . Lacey, D.L. et al. (1998) Cell 93, 165-76. 4 . Yasuda, H. et al. (1998) Proc. Natl. Acad. Sci. USA 95, 3597-602. 5 . Darnay, B.G. et al. (1998) J Biol Chem 273, 20551-5. 6 . Wong, B.R. et al. (1999) Mol Cell 4, 1041-9. 7 . Walsh, M.C. and Choi, Y. Cytokine Growth Factor Rev. 14, 251-63. 8 . Nakashima, T. et al. (2003) Curr. Opin. Rheumatol. 15, 280-7. |
Western blot analysis of extracts from K562 (human), KNRK (rat) and C2C12 (mouse) cell lines, using RANK Antibody.Western免疫印迹。用 RANK Antibody研究K562 (人源), KNRK (大鼠源) 和 C2C12 (小鼠源)细胞系的细胞提取液。 | |
Western blot analysis of extracts from HeLa cells mock transfected or transfected with mRANK, using RANK Antibody.Western免疫印迹。用RANK Antibody研究对照转染和转染了mRANK HeLa 细胞的细胞提取液。 |
