| 货号 | 3526S |
| 反应种属 | Human/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | RalA Antibody detects endogenous levels of total human RalA protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | RalA and RalB are members of the Ras family of small GTPases and are highly homologous in protein sequence. The functions of RalA and RalB are distinct yet overlapping. By binding to various effector proteins, RalA and RalB serve as important GTP sensors for exocytosis and membrane trafficking (1-3). RalA is required for Ras-related tumorigenesis (4) and RalB is important for tumor survival (5). In addition to tumor formation, Ral proteins also play a role in cancer cell migration and metastatic tumor invasion (6,7). |
| 存放说明 | -20C |
| 计算分子量 | 25 |
| 参考文献 | 1 . Li, G. et al. (2007) J Neurosci 27, 190-202. 2 . van Dam, E.M. and Robinson, P.J. (2006) Int J Biochem Cell Biol 38, 1841-7. 3 . Camonis, J.H. and White, M.A. (2005) Trends Cell Biol 15, 327-32. 4 . Lim, K.H. et al. (2005) Cancer Cell 7, 533-45. 5 . Chien, Y. et al. (2006) Cell 127, 157-70. 6 . Oxford, G. et al. (2005) Cancer Res 65, 7111-20. 7 . Lim, K.H. et al. (2006) Curr Biol 16, 2385-94. |
Western blot analysis of extracts from various cell lines using RalA Antibody. 使用RalA Antibody，免疫印迹（Western Blot）分析不同细胞中RalA蛋白水平。 |
