| 货号 | 4879S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Rab6 Antibody detects endogenous levels of total Rab6 protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Rab6 is a member of the Ras superfamily of small Rab GTPases implicated in endocytosis (1). The three distinct members of the Rab6 subfamily (Rab6A, Rab6A and Rab6B) are structurally similar but likely exhibit non-overlapping functions (2,3). Rab6 localized to the Golgi (4) regulates retrograde transport of membrane-bound target proteins from the Golgi apparatus to the endoplasmic reticulum (5-7) or from the Golgi to the endosome during exocytotic transport (8). Rab6 interacts with microtubule motor proteins such as rabkinesin-6 (KIF20A) and dynein/dynactin complexes; Rab6 related transport requires a functionally intact, microtubule system (9,10). Rab6 proteins help regulate cytokinesis and cell cycle check point through interactions with Rab6 effector proteins, including the dynein/dynactin protein DCTN1 and the GTPase activating protein RABGAP1 (11,12). |
| 存放说明 | -20C |
| 计算分子量 | 24 |
| 参考文献 | 1 . Zerial, M. and McBride, H. (2001) Nat Rev Mol Cell Biol 2, 107-17. 2 . Echard, A. et al. (2000) Mol Biol Cell 11, 3819-33. 3 . Del Nery, E. et al. (2006) Traffic 7, 394-407. 4 . Goud, B. et al. (1994) Ann N Y Acad Sci 733, 340-3. 5 . White, J. et al. (1999) J Cell Biol 147, 743-60. 6 . Opdam, F.J. et al. (2000) J Cell Sci 113 ( Pt 15), 2725-35. 7 . Martinez, O. et al. (1997) Proc Natl Acad Sci USA 94, 1828-33. 8 . Grigoriev, I. et al. (2007) Dev Cell 13, 305-14. 9 . Echard, A. et al. (1998) Science 279, 580-5. 10 . Young, J. et al. (2005) Mol Biol Cell 16, 162-77. 11 . Hill, E. et al. (2000) EMBO J 19, 5711-9. 12 . Miserey-Lenkei, S. et al. (2006) EMBO J 25, 278-89. |
Western blot analysis of extracts from various cell lines and tissues using Rab6 Antibody. 对多个细胞系和组织使用Rab6 Antibody进行Western blot分析。 |
