| 货号 | 9690S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Rab35 Antibody detects endogeneous levels of total Rab35 protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Rab35 belongs to the small GTPase superfamily. By interacting with its specific GEF or GAP, Rab35 regulates cargo-specific endocytosis at the vesicle recycling step or mediates exocytosis at the exosome docking/tethering step (1-4). During cytokinesis, Rab35 interacts with OCRL phosphatase and is essential for maintaining intercellular bridge stability and abscission by controlling the concentration of phosphatidylinositol 4,5-bisphosphate (PIP2) and SEPT2 localization at the intercellular bridge (5,6). Rab35 also plays a role in actin assembly and the recruitment of Cdc42 and Rac1 to the site of filopodium by its direct interaction with actin-bundling protein fascin and actin-binding protein connecdenn 3 (7-9). |
| 存放说明 | -20C |
| 计算分子量 | 24 |
| 参考文献 | 1 . Patino-Lopez, G. et al. (2008) J Biol Chem 283, 18323-30. 2 . Sato, M. et al. (2008) EMBO J 27, 1183-96. 3 . Marat, A.L. and McPherson, P.S. (2010) J Biol Chem 285, 10627-37. 4 . Hsu, C. et al. (2010) J Cell Biol 189, 223-32. 5 . Kouranti, I. et al. (2006) Curr Biol 16, 1719-25. 6 . Dambournet, D. et al. (2011) Nat Cell Biol 13, 981-8. 7 . Zhang, J. et al. (2009) Science 325, 1250-4. 8 . Marat, A.L. et al. (2012) Mol Biol Cell 23, 163-75. 9 . Shim, J. et al. (2010) Mol Cell Biol 30, 1421-33. |
Western blot analysis of extracts from various cell lines using Rab35 Antibody.使用Rab35抗体对多种细胞提取物进行western blot分析。 |
