| 货号 | 3539S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Rab11 Antibody detects endogenous levels of total Rab11 protein, including isoforms Rab11a and Rab11b. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Rab11a, Rab11b and Rab25 are members of the Rab11 family of small Ras-like GTPases. Rab11 (isoforms Rab11a and Rab11b) functions as a key regulator in the recycling of perinuclear, plasma membrane and Golgi compartment endosomes (1,2). Despite some overlap, distinct differences exist between Rab11a and Rab11b in both their cellular distribution and functional roles. Rab11a is ubiquitously expressed while Rab11b is found mainly in the heart and brain (3,4). Like other Rab proteins, Rab11 exerts its function via interactions with Rab11 family interacting proteins (FIPs). While there are three distinct classes of FIPs, all appear to share a conserved carboxy-terminal Rab-binding domain that allows Rab-FIP protein interaction. When bound together, these proteins are thought to regulate membrane-associated protein sorting (5,6). |
| 存放说明 | -20C |
| 计算分子量 | 25 |
| 参考文献 | 1 . Ullrich, O. et al. (1996) J Cell Biol 135, 913-24. 2 . Chen, W. et al. (1998) Mol Biol Cell 9, 3241-57. 3 . Lapierre, L.A. et al. (2003) Exp Cell Res 290, 322-31. 4 . Khvotchev, M.V. et al. (2003) J Neurosci 23, 10531-9. 5 . Junutula, J.R. et al. (2004) J Biol Chem 279, 33430-7. 6 . Hales, C.M. et al. (2001) J Biol Chem 276, 39067-75. |
Western blot analysis of extracts from A549, Neuro-2A and COS cells using Rab11 Antibody. 对A549, Neuro-2A和COS细胞裂解液使用Rab11 Antibody进行Western blot分析。 |
