| 货号 | 2507S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP/IF-F |
| 目标/特异性 | PSD95 Antibody detects endogenous levels of total PSD95 protein. |
| 使用方法 | WB(1:1000) IP (1:50) IF-F (1:100) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Postsynaptic Density protein 95 (PSD95) is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. These family members consist of an amino-terminal variable segment followed by three PDZ domains, a SH3 domain and an inactive guanylate kinase (GK) domain. PSD95 is a scaffolding protein involved in the assembly and function of the postsynaptic density complex (1-2). PSD95 participates in synaptic targeting of AMPA receptors through an indirect manner involving Stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs) (3). It is implicated in experience dependent plasticity and plays an indispensable role in learning (4). Mutations in PSD95 are associated with autism (5). |
| 存放说明 | -20C |
| 计算分子量 | 95 |
| 参考文献 | 1 . Cao, J. et al. (2005) J. Cell Biol 168, 117-26. 2 . Chetkovich, D.M. et al. (2002) J. Neurosci. 22, 6415-25. 3 . Cai, C. et al. (2006) J. Biol. Chem. 281, 4267-73. 4 . Yao, W.D. et al. (2004) Neuron 41, 625-38. 5 . Cline, H. (2005) Curr. Biol. 15, R203-5. |
Western blot analysis of extracts from mouse and rat brain, using PSD95 Antibody. Western blot分析小鼠大脑和大鼠大脑提取物，使用的抗体是PSD95 Antibody 兔多抗。 | |
Confocal immunofluorescent image of rat retina labeled with PSD95 Antibody (red) and Akt (5G3) Mouse mAb #2966 (green). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye). 共聚焦免疫荧光分析大鼠视网膜，使用PSD95 Antibody 兔多抗（红色）和Akt (5G3) Mouse mAb 鼠单抗#2966（绿色）进行标记。蓝色伪彩=DRAQ5® #4084(荧光DNA染料)。 |
