| 货号 | 12300S |
| 反应种属 | Human/Mouse/Rat/Hamster/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Pontin/RUVBL1 Antibody recognizes endogenous levels of total Pontin/RUVBL1 protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Reptin/RuvBL2 and Pontin/RuvBL1 are closely related members of the AAA+ (ATPase Associated with diverse cellular Activities) superfamily of proteins, and are putatively homologous to bacterial RuvB proteins that drive branch migration of Holliday junctions (1). Reptin and Pontin function together as essential components of chromatin remodeling and modification complexes, such as INO80, TIP60, SRCAP, and Uri1, which play key roles in regulating gene transcription (1,2). In their capacity as essential transcriptional co-regulators, Reptin and Pontin have both been implicated in oncogenic transformations, including those driven by c-Myc, β-catenin, and E1A (2-7). |
| 存放说明 | -20C |
| 计算分子量 | 50 |
| 参考文献 | 1 . Jha, S. and Dutta, A. (2009) Mol Cell 34, 521-33. 2 . Gallant, P. (2007) Trends Cell Biol 17, 187-92. 3 . Huber, O. et al. (2008) Cancer Res 68, 6873-6. 4 . Kim, J.H. et al. (2005) Nature 434, 921-6. 5 . Bauer, A. et al. (2000) EMBO J 19, 6121-30. 6 . Wood, M.A. et al. (2000) Mol Cell 5, 321-30. 7 . Dugan, K.A. et al. (2002) Oncogene 21, 5835-43. 8 . Huber, O. et al. (2008) Cancer Res 68, 6873-6. 9 . Matsuoka, S. et al. (2007) Science 316, 1160-6. 10 . Blanc, J.F. et al. (2005) Proteomics 5, 3778-89. 11 . Lauscher, J.C. et al. (2007) Hum Pathol 38, 978-85. 12 . Jha, S. et al. (2008) Mol Cell Biol 28, 2690-700. |
Western blot analysis of extracts from various cell lines using Pontin/RUVBL1 Antibody.Western blot方法检测不同细胞系的提取物，使用的抗体为Pontin/RUVBL1 Antibody。 |
