| 货号 | 3813S |
| 反应种属 | Human/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | Plexin A1 Antibody detects endogenous levels of total Plexin A1 protein. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Class 3 secreted semaphorin (Sema3A) is a chemorepellent that acts upon a wide variety of axons. As such, it induces a dramatic redistribution and depolymerization of actin filaments that results in growth cone collapse. Plexins are single membrane-spanning signaling proteins encompassing Plexin A1, A2, A3, and A4. Plexins form a complex with neuropilin-1 and -2 and the cell adhesion protein L1 to form a functional semaphorin receptor (1,2). The GTPase Rnd1 binds to the cytoplasmic domain of Plexin A1 to trigger cytoskeletal collapse. In contrast, the GTPase RhoD blocks Rnd1-mediated Plexin A1 activation and repulsion of sympathetic axons by Sema3A (3). |
| 存放说明 | -20C |
| 计算分子量 | 211 |
| 参考文献 | 1 . Pasterkamp, R.J. and Kolodkin, A.L. (2003) Curr Opin Neurobiol 13, 79-89. 2 . Takahashi, T. and Strittmatter, S.M. (2001) Neuron 29, 429-39. 3 . Zanata, S.M. et al. (2002) J Neurosci 22, 471-7. |
Western blot analysis of extracts from fetal rat brain and K562 cells using Plexin A1 Antibody. Western blot分析胎大鼠大脑和K562细胞提取物，使用的抗体是Plexin A1 Antibody 兔多抗。 | |
