| 货号 | 8962S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | PLA2G1B Antibody recognizes endogenous levels of total PLA2G1B protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Phospholipase A2 (PLA2) is a superfamily of enzymes that hydrolyze glycero-3-phosphocholines and release fatty acids and lysophospholipids (1). PLA2G1B is a member of this superfamily in the 1B group that is expressed most highly in the pancreatic acinar cells (2). Evidence suggests that PLA2G1B plays a role in the absorption and storage of extra energy as fats are metabolized (1,2). Lysophospholipids generated by PLA2G1B inhibit fatty acid oxidation in the liver and reduce energy expenditure, leading to diet-induced obesity and type 2 diabetes with a high fat diet (1). Therefore, a potential intervention of obesity and diabetes could target PLA2G1B in the digestive tract (2). |
| 存放说明 | -20C |
| 计算分子量 | 16 |
| 参考文献 | 1 . Labonté, E.D. et al. (2010) FASEB J 24, 2516-24. 2 . Cash, J.G. et al. (2011) Int J Obes (Lond) 35, 877-81. |
Western blot analysis of extracts from human pancreas and kidney tissue using PLA2G1B Antibody (upper) and β-Actin (13E5) Rabbit mAb #4970 (lower). 对人胰腺或肾组织使用PLA2G1B Antibody（上图）或β-Actin (13E5) Rabbit mAb兔单抗 #4970（下图）进行Western blot分析。 |
