| 货号 | 65055S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | WB |
| 目标/特异性 | CD59 Antibody recognizes endogenous levels of total CD59 protein. |
| 使用方法 | W |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | CD59 is a GPI-anchored membrane protein that functions as inhibitor of the complement membrane attack complex (MAC). CD59 binds to complement components C8 and C9, preventing C9 polymerization and insertion into membranes, therefore inhibiting the complement-dependent cytolysis (CDC) (1). CD59 is a ubiquitously expressed cell membrane protein that protects cells from CDC. Rare cases of CD59 deficiency have been reported to cause paroxysmal nocturnal hemoglobinuria in human patients (2,3). Expression of CD59 on tumor cells and viral infected cells makes them resist antibody-dependent complement-mediated lysis. Potent inhibitors for CD59 have been actively pursued for therapeutic applications (4,5). In addition, CD59 may regulate insulin secretion by modulating exocytosis (6). |
| 存放说明 | -20C |
| 计算分子量 | 18 |
| 参考文献 | 1 . Sugita, Y. and Masuho, Y. (1995) Immunotechnology 1, 157-68. 2 . Mevorach, D. (2015) Mol Immunol 67, 51-5. 3 . Höchsmann, B. and Schrezenmeier, H. (2015) Hematol Oncol Clin North Am 29, 495-507. 4 . Cai, B. et al. (2014) J Biol Chem 289, 12109-25. 5 . Lan, J. et al. (2014) J Immunol 193, 3577-89. 6 . Krus, U. et al. (2014) Cell Metab 19, 883-90. |
Western blot analysis of extracts from various cell lines using CD59 Antibody (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower). |
