| 货号 | 64099S |
| 反应种属 | Human, Mouse, Rat |
| 来源宿主 | Rabbit |
| 应用 | WB,IP |
| 目标/特异性 | LRP1 Antibody recognizes endogenous levels of total LRP1 β subunit. |
| 使用方法 | Western Blotting (1:1000) Immunoprecipitation (1:50) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Low density lipoprotein receptor related protein 1 ( LRP1) is a type I transmembrane receptor that mediates the endocytosis of various ligands (1). LRP1 plays important roles in lipid homeostasis, signaling transduction, embryonic development, and glucose metabolism (2-6). In addition, LRP1 regulates APP processing and facilitates the clearance of beta-amyloid (7-9). This finding makes LRP1 a potential therapeutic target for Alzheimer’s disease. LRP1 preprotein is proteolytically processed by furin to generate a 515 kDa extracellular α subunit and a membrane-anchored 85 kDa β subunit, which together form the mature receptor (10). |
| 存放说明 | -20C |
| 计算分子量 | 85 |
| 参考文献 | 1 . Lillis, A.P. et al. (2008) Physiol Rev 88, 887-918. 2 . Herz, J. et al. (1988) EMBO J 7, 4119-27. 3 . van der Geer, P. (2002) Trends Cardiovasc Med 12, 160-5. 4 . May, P. and Herz, J. (2003) Traffic 4, 291-301. 5 . Zilberberg, A. et al. (2004) J Biol Chem 279, 17535-42. 6 . Hofmann, S.M. et al. (2007) J Clin Invest 117, 3271-82. 7 . Cam, J.A. et al. (2005) J Biol Chem 280, 15464-70. 8 . Bu, G. et al. (2006) Ann N Y Acad Sci 1086, 35-53. 9 . Bell, R.D. et al. (2009) Nat Cell Biol 11, 143-53. 10 . Willnow, T.E. et al. (1996) Biochem J 313 ( Pt 1), 71-6. |
Western blot analysis of extracts from U-87 MG and A549 cells using LRP1 Antibody. |
