PC1/3 Antibody
货号：
11914S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 11914S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | PC1/3 Antibody recognizes endogenous levels of total PC1/3 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | The proprotein convertases (PCs) are enzymes that activate precursor proteins through proteolytic cleavage within the secretory pathway. PCs comprise several enzymes that are basic amino acid-specific proteinases (furin, PC1/3, PC2, PC4, PACE4, PC5/6, and PC7), as well as nonbasic amino acid convertases (S1P and PC9) (1). PCs have a common structure that includes an N-terminal signal peptide for secretory pathway targeting; a pro-domain that is thought to act as an intramolecular chaperone; a catalytic domain containing the active site; a P-domain that contributes to the overall folding of the enzyme by regulating stability, calcium-, and pH-dependence; and a C-terminal domain that interacts with the membrane (2). PCs act in a tissue- and substrate-specific fashion to generate an array of bioactive peptides and proteins from precursors, both in the brain and the periphery (3). Research studies examining the PCSK1 gene (encoding PC1/3) suggest that mutations that cause impaired PC1/3 expression or enzymatic activity contribute to obesity (4). |
| 存放说明 | -20C |
| 计算分子量 | 70 |
参考图片Western blot analysis of extracts from mouse cortex, wild-type (WT) and PC1/3 (-/-) mouse hypothalamus, and human hypothalamus using PC1/3 Antibody (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower). Tissues from WT and PC1/3 (-/-) mice were kindly provided by Dr. Robert Day (University of Sherbrooke, Quebec, Canada). Western blot分析从小鼠皮层、野生型（WT）和PC1/3(-/-) 缺失型小鼠下丘和人下丘脑的提取物，使用的抗体是PC1/3 Antibody兔多抗 （上图）或β-Actin (D6A8) Rabbit mAb兔单抗 #8457 （下图）。WT和PC1/3(-/-) 小鼠组织由 Robert Day博士赠送（舍布鲁克大学，魁北克省，加拿大）。 |
