PAX3 Antibody
货号：
12412S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 12412S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | PAX3 Antibody recognizes transfected levels of total PAX3 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Paired box (PAX) proteins are a family of transcription factors that play important and diverse roles in animal development (1). Nine PAX proteins (PAX1-9) have been described in humans and other mammals. They are defined by the presence of an amino-terminal "paired" domain, consisting of two helix-turn-helix motifs, with DNA binding activity (2). PAX proteins are classified into four structurally distinct subgroups (I-IV) based on the absence or presence of a carboxy-terminal homeodomain and a central octapeptide region. Subgroup I (PAX1 and 9) contains the octapeptide but lacks the homeodomain; subgroup II (PAX2, 5, and 8) contains the octapeptide and a truncated homeodomain; subgroup III (PAX3 and 7) contains the octapeptide and a complete homeodomain; and subgroup IV (PAX4 and 6) contains a complete homeodomain but lacks the octapeptide region (2). PAX proteins play critically important roles in development by regulating transcriptional networks responsible for embryonic patterning and organogenesis (3); a subset of PAX proteins also maintain functional importance during postnatal development (4). Research studies have implicated genetic mutations that result in aberrant expression of PAX genes in a number of cancer subtypes (1-3), with members of subgroups II and III identified as potential mediators of tumor progression (2). |
| 存放说明 | -20C |
| 计算分子量 | 62 |
参考图片Western blot analysis of extracts from 293 cells, mock transfected (-) or transfected with a construct expressing Myc/DDK-tagged full-length human PAX3 (hPAX3-Myc/DDK; +), using PAX3 Antibody (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower). 空转染对照（-）或转染了表达含有Myc/DDK标签的全长人PAX3 (hPAX3-Myc/DDK; +)的293细胞提取物，使用PAX3抗体（上）或β-Actin (D6A8) Rabbit mAb 兔单抗#8457（下）进行western blot分析。 |
