| 货号 | 11939S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Oligophrenin-1 Antibody recognizes endogenous levels of total Oligophrenin-1 protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 背景 | Oligophrenin-1 is a RhoGTPase-activating protein encoded by the gene OPHN1 (1). Oligophrenin-1 is composed of an N-terminal BAR domain, a pleckstrin homology domain, a central RhoGAP domain, and three putative C-terminal SH3-binding sites. Oligophrenin-1 plays a role in membrane signaling through interaction of its BAR domain with curved membranes, binding of its pleckstrin homology domain with membrane phosphoinositides, and interaction of the SH3-binding sites with adaptor proteins (1-3). Oligophrenin-1 regulates synaptic vesicle endocytosis (3) and plays an important role in dendritic spine morphogenesis (4). Furthermore, by interacting with the transcription factor Rev-erbα and protecting it from degradation, Oligophrenin-1 participates in the regulation of the circadian rhythm in the hippocampus (5). Research studies have demonstrated an involvement of Oligophrenin-1 in X-linked mental retardation (1). |
| 存放说明 | -20C |
| 计算分子量 | 92 |
Western blot analysis of extracts from various tissues and cell lines using Oligophrenin-1 Antibody. Western blot 检测多种组织和细胞系提取物，使用的抗体是Oligophrenin-1 Antibody兔多抗。 | |
Western blot analysis of extracts from HeLa cells, mock transfected (-) or transfected with a construct expressing Myc-tagged full-length human Oligophrenin-1 (Oligophrenin-1-Myc; +), using Oligophrenin-1 Antibody. Western blot方法检测HeLa细胞提取物：空质粒转染（-）或带Myc -标签全长人Oligophrenin-1 (Oligophrenin-1-Myc; +)质粒转染；使用的抗体是Oligophrenin-1 Antibody兔多抗。 |
