OB-Cadherin (P707) Antibody【科瑞奥博】

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OB-Cadherin (P707) Antibody

货号： 4442S 基本售价： 3360.0 元规格： 100ul

产品信息

概述
货号	4442S
反应种属	Human/Mouse/Rat
来源宿主	Rabbit
应用	W/IP/IF-IC
目标/特异性	OB-Cadherin (P707) Antibody detects endogenous levels of total OB-cadherin protein.
使用方法	WB(1:1000) IP (1:100) IF-IC (1:100)

性能
供应商	CST
背景	Cadherins are a superfamily of transmembrane glycoproteins that contain cadherin repeats of approximately 100 residues in their extracellular domain. Cadherins mediate calcium-dependent cell-cell adhesion and play critical roles in normal tissue development (1). The classic cadherin subfamily includes N-, P-, R-, B- and E-cadherins as well as about ten other members that are found in adherens junctions, a cellular structure near the apical surface of polarized epithelial cells. The cytoplasmic domain of classical cadherins interacts with β-catenin, γ-catenin (also called plakoglobin), and p120 catenin. β-catenin and γ-catenin associate with α-catenin, which links the cadherin-catenin complex to the actin cytoskeleton (1,2). While β- and γ-catenin play structural roles in the junctional complex, p120 regulates cadherin adhesive activity and trafficking (1-4). E-cadherin is considered an active suppressor of invasion and growth of many epithelial cancers (1-3). Recent studies indicate that cancer cells have up-regulated N-cadherin in addition to loss of E-cadherin. This change in cadherin expression is called the "cadherin switch". N-cadherin cooperates with the FGF receptor, leading to over-expression of MMP-9 and cellular invasion (3). In endothelial cells, VE-cadherin signaling, expression, and localization correlate with vascular permeability and tumor angiogenesis (5,6). Expression of P-cadherin, which is normally present in epithelial cells, is also altered in ovarian and other human cancers (7,8).
存放说明	-20C
计算分子量	120

参考图片

Western blot analysis of extracts from NCI-H460 and MDA-MB-231 cells using OB-Cadherin (P707) Antibody.使用OB-Cadherin (P707)抗体对NCI-H460和MDA-MB-231细胞提取物进行western blot分析。

Confocal immunofluorescent analysis of PC-3 (positive, left) and LNCaP (negative, right) cells using OB-Cadherin (P707) Antibody (green). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye).使用OB-Cadherin (P707) 抗体（绿色）对PC-3（阳性，左）和LNCaP（阴性，右）细胞进行激光共聚焦荧光分析。蓝色假色= DRAQ5® #4084 （DNA荧光染料）。