| 货号 | 8066S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 背景 | Nuclear Receptor Binding Factor-2 (NRBF-2), also referred to as Comodulator of PPAR and RXRα-2 (COPR-2), has been shown to interact with the AF-2 region of several nuclear hormone receptors with varying affinities such as PPARα, RARα, RARγ, and RXRα (1,2). NRBF-2 contains a LLYLL motif, which matches the LXXLL NR box consensus and is required for functional NRBF-2/nuclear receptor complex formation and repression of receptor function. NRBF-2 also contains a unique autonomous activation domain and thus, does not completely abrogate nuclear receptor function, suggesting that NRBF-2 might serve as a molecular rheostat to fine-tune the transcriptional activity of liganded nuclear receptors (1,2).核受体结合因子-2（NRBF-2）也被称为PPAR和RXRα-2（COPR-2）的共调节子，已被证明其与一些核激素受体AF-2区域有不同的亲和力，如PPARα、RARα、 RARγ 和RXRα（1,2）。 NRBF-2包含一个LLYLL模体，与LXXLL NR框相匹配，对于功能性NRBF-2/核受体复合物的形成和抑制受体功能是需要的。NRBF-2还包含一个独特的自主激活结构域，因此不能完全去除核受体的功能，这表明NRBF-2可能作为一个分子可变电阻器，以微调已配位核受体的转录活性（1,2）。 |
| 存放说明 | -20C |
| 计算分子量 | 40 |
Western blot analysis of extracts from various cell lines using NRBF-2 Antibody.Western blot方法检测多个细胞系的提取物，使用的抗体为NRBF-2 Antibody. | |
Western blot analysis of extracts from 293T cells, either mock transfected (-) or transfected with a Myc/DDK-tagged full-length human NRBF-2 construct (+), using NRBF-2 Antibody.Western blot方法检测293T细胞的提取物，细胞不转染(-)或用Myc/DDK标记的全长人NRBF-2构建体转染(+)，使用的抗体为NRBF-2 Antibody. |
