Nod1 Antibody
货号：
3545S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3545S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Nod1 Antibody detects endogenous levels of Nod1 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Nod1/CARD4 is a cytosolic protein structually related to Apaf-1 and plant drug-resistance proteins that has been implicated in apoptosis and inflammatory responses to certain pathogenic bacteria (1-3). It contains an amino-terminal caspase recruitment domain (CARD) that is linked to a central nucleotide-binding domain (NBD; also known as a NOD domain) and is followed by carboxy-terminal leucine-rich repeats (LRR) (1). Like Apaf-1, Nod1 induces apoptosis by a CARD/NBD-dependent activation of caspase-9 (1). The primary function of Nod1 is thought to be as a sensor for certain pathogenic microbes and triggering inflammatory responses including the activation of NF-κB and JNK pathways (4-6). The LRR of Nod1 appears to be involved in recognition of microbial components and the CARD domain induces NF-κB activation in cooperation with the CARD containing kinase, RICK/RIP2/CARDIAK (1,5,6). Mutations in Nod1 have been linked increased susceptibility to asthma (7) and inflammatory bowel disease (8). |
| 存放说明 | -20C |
| 计算分子量 | 95 |
参考图片Western blot analysis of extracts from SR (human), 4T1 (mouse) and C6 (rat) cell lines using Nod1 Antibody.Western免疫印迹。用Nod1 Antibody研究SR (人源), 4T1 (小鼠源) 和 C6 (大鼠源) 细胞系的细胞提取液。 |
