NG2 Antibody
货号：
4235S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4235S |
| 反应种属 | Human/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | NG2 Antibody detects endogenous levels of total NG2 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | The chondroitin sulfate proteoglycan NG2 is a type I membrane protein expressed by subpopulations of glia including oligodendroglial precursor cells and a variety of tumor cells. Normal precursor cells and malignant tumor cells migrate and proliferate, but there is evidence that cells may not be able to engage in both activities at the same time. However, NG2 is involved in promoting both proliferation and motility (1). The extracellular domain of NG2 sequesters growth factors and binds to both growth factor receptors and extracellular matrix ligands such as fibronectin, collagens and laminin. The cytoplasmic domain is involved in activating Rac, Cdc42 and p130 Cas (2). PKCα phosphorylates NG2 at Thr2256, triggering the redistribution of NG2 from apical microprocesses to lamellipodia accompanied by enhanced cell motility (3). ERK phosphorylates NG2 at Thr2314, stimulating cell proliferation (4). |
| 存放说明 | -20C |
| 计算分子量 | 250 |
参考图片Western blot analysis of extracts from MDA-MB-468 and RN33B cells using NG2 Antibody. Western blot分析MDA-MB-468和RN33B细胞提取物，使用的抗体是NG2 Antibody 兔多抗。 |
