NALP1 Antibody
货号：
4990S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4990S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | NALP1 Antibody detects endogenous levels of total NALP1 protein. This antibody also detects a 70 kDa protein that correlates with a predicted short form (NALP1s) that lacks the leucine repeat region (7). |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | NALP1 (DEFCAP/NAC/CARD7) is an NLR (Nod-like receptor) family member that has been implicated in the regulation of apoptosis and inflammatory responses (1-5). Structurally, NALP contains an amino-terminal PYRIN domain, followed by a nucleotide-binding site (NBS), a leucine rich repeat region (LRR), and a carboxy-terminal CARD domain. NALP1 and interacts strongly with caspase-2 and weakly with caspase-9, and induces apoptosis when overexpressed (3). Similar to a related Ced-4 family member Apaf-1, it was also shown to be involved in cytochrome c-dependent caspase activation (2). It has also been shown to be part of the "inflammasome" comprised of caspase-1, caspase-5, and Pycard/ASC, which is critical in the processing of pro-inflammatory cytokines like IL-1β (6). Two major isoforms were identified for NALP1, which differ in a 44 amino acid region within the LRR (3). In addition, like NALP3, a short NALP1 isoform lacking the LRR (NALP1s) likely exists (7). Polymorphisms in NALP1 have been associated with autoimmune disease (8) and susceptibility to toxins (9). |
| 存放说明 | -20C |
| 计算分子量 | 165, 70 |
参考图片Western blot analysis of extracts from K-562 and SH-SY5Y cells and from rat testis using NALP1 Antibody. |
