NAC1 Antibody (Human Preferred)
货号：
4420S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4420S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | NAC1 Antibody (Human Preferred) detects endogenous levels of total NAC1 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | NAC1 or nuclear accumbens-1 is a nuclear factor that belongs to the POZ/BTB (Pox virus and zinc finger/bric-a-brac tramtrack broad complex) domain family. Also known as BTBD14B, it was originally identified in a unique neuronal forebrain structure responsible for reward motivation and addictive behaviors (1,2). NAC1 recruits HDAC3 and HDAC4 to transcriptionally repress gene expression in neuronal cells (3) and specifically co-represses other POZ/BTB proteins in the central nervous system (4). NAC1 is upregulated in several tumor types, including breast, renal cell, and hepatocellular carcinoma, as well as high grade ovarian serous carcinoma, where it has long been suspected as a chemoresistance gene (5,6). The chemoresistance mechanism reportedly occurs through NAC1 negative regulation of the GADD45 pathway (7). NAC1 has also been described as part of the extended transcriptional network in pluripotent cells that involves Oct-4, Sox2, Nanog, Sall1, KLF4 and Sall4 (8). |
| 存放说明 | -20C |
| 计算分子量 | 62 |
参考图片Western blot analysis of extracts from various tissue and cell lines using NAC1 Antibody (Human Preferred).使用NAC1 抗体 (Human Preferred)对多种组织和细胞提取物进行western blot分析。 |
