MIS-R2 Antibody
货号：
4518S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4518S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | MIS-R2 Antibody detects transfected levels of human MIS-R2 protein. |
| 使用方法 | WB(1:1000)
IP (1:50) |
性能| 供应商 | CST |
| 背景 | The type II receptor for Müllerian inhibiting substance (MIS), also known as the anti-Müllerian hormone receptor 2 (AMHR2), binds a hormone-ligand that directs the incomplete development of Müllerian ducts in male embryos (1,2). MIS-R2 is a single transmembrane serine/threonine kinase receptor of the TGF-β receptor family involved in the phosphorylation of shared type 1 receptors and Smad transcriptional regulators (3,4). MIS produced by the fetal testis promotes the regression of Müllerian ducts that would otherwise differentiate into the uterus and fallopian tubes in the male fetus (5). Corresponding MIS-R2 gene mutations can cause persistent Müllerian duct syndrome type 2 (PMDS-2), a form of male pseudohermaphroditism characterized by a failure of Müllerian duct regression (6). The presence of MIS-R2 is observed in ovarian cancer cell lines that respond positively to treatment with recombinant MIS, suggesting that both receptor and ligand may be important therapeutic tools (7). |
| 存放说明 | -20C |
| 计算分子量 | 75-85 |
参考图片Western blot analysis of extracts from COS cells, mock transfected or transfected with human myc-tagged MIS-R2, using MIS-R2 Antibody (construct kindly provided by Drs. David MacLaughlin and Patricia Donahoe, Massachusetts General Hospital).COS细胞经过myc-标记的MIS-R2转染或未转染后进行western blot分析，使用MIS-R2抗体孵育（马萨诸塞综合医院Drs. David MacLaughlin 和Patricia Donahoe构建并提供）。 |
