Mic-1 (L300) Antibody
货号：
3209S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3209S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Mic-1 (L300) Antibody detects endogenous levels of total Mic-1 protein including its active processed form. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Macrophage inhibitory cytokine-1 (Mic-1), also termed GDF15 (1), PTGF-β (2), PLAB (3), PDF (4), and NAG-1 (5) is a divergent member of the transforming growth factor-β (TGF-β) superfamily (6). Like other family members, Mic-1 is synthesized as an inactive precursor that undergoes proteolytic processing involving removal of an N-terminal hydrophobic signal sequence followed by cleavage at a conserved RXXR site generating an active C-terminal domain that is secreted as a dimeric protein. Mic-1 is highly expressed in the placenta and is also dramatically increased by cellular stress, acute injury, inflammation, and cancer. In the brain, Mic-1 is found in the choroid plexus and is secreted into the cerebrospinal fluid (7). It is also a transcriptional target of the p53 tumor suppressor protein and may serve as a biomarker for p53 activity (8,9). During tumor progression, Mic-1 has various effects on apoptosis, differentiation, angiogenisis, and metastasis, and may also contribute to weight loss during cancer (10,11). |
| 存放说明 | -20C |
| 计算分子量 | 35, 13 |
参考图片Western blot analysis of extracts from HT-1080 cells, untreated or treated with TPA, TNF-α or TGF-β (6 hrs), using Mic-1 (L300) Antibody.使用Mic-1（L300）抗体对未处理或经过TPA TNF-α或TGF-β （6小时）处理的HT-1080细胞提取物进行western blot分析。 |
Western blot analysis of recombinant mature Mic-1 protein using Mic-1 (L300) Antibody.使用Mic-1 (L300) 抗体对重组成熟Mic-1蛋白进行western blot分析。 |
