MGMT Antibody
货号：
2739S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 2739S |
| 反应种属 | Human/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | MGMT (O-6-methylguanine-DNA methyltransferase) is a DNA repair enzyme that participates in a suicide reaction that specifically removes methyl or alkyl groups from the O(6) position of guanine, restoring guanine to its normal form without causing DNA breaks (1). MGMT protects cells from alkylating toxins, and is an important factor in drug resistance to alkylating therapeutic agents (2,3). It is ubiquitously expressed in normal human tissues (4) and is overexpressed in many types of human tumors, but epigenetically silenced in other tumors. MGMT silencing is a marker associated with poor prognosis, but is a good predictive marker for response to alkylating agent chemotherapy (5).MGMT（O-6-甲基鸟嘌呤-DNA甲基转移酶）是一种DNA修复酶，参与自杀反应，特异性的清除鸟嘌呤6位O的甲基或烷基官能团，恢复鸟嘌呤到其正常形式且不造成DNA断裂(1)。MGMT可以保护细胞免受烷化毒素的损害，是针对烷化治疗药物抵抗的重要因子(2,3)。它在正常的人体组织中广泛表达(4)，在多种人类肿瘤中过度表达而在其它一些肿瘤中表观沉默。MGMT沉默是不良预后的相关标志，但是在烷化剂化疗过程中是一个很好的预测指标(5)。 |
| 存放说明 | -20C |
| 计算分子量 | 21 |
参考图片Western blot analysis of extracts from Jurkat and MOLT4 cells using MGMT Antibody.western blot方法检测Jurkat和MOLT4细胞提取物，使用的抗体为MGMT Antibody。 |
