| 货号 | 19607S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 背景 | Mitogen-activated protein kinase kinase kinase 2 (MEKK2/MAP3K2) belongs to the MAP3K family of Ser/Thr kinases. Research studies have demonstrated that MEKK2 plays a pivotal role in transducing mitogenic signals emanating from EGFR and FGF2R to JNK and ERK5 signaling cascades (1,2). Post-translationally MEKK2 is regulated through multiple mechanisms including: dimerization (3,4), ubiquitination (5,6), phosphorylation (7) and methylation (8). Research studies implicate dysregulation of MEKK2 signaling in breast carcinoma (9), colorectal carcinoma (10), and pancreatic ductal adenocarcinoma (8). |
| 存放说明 | -20C |
| 计算分子量 | 78 |
Western blot analysis of extracts from various cell lines using MEKK2 Antibody. | |
Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with a construct expressing Myc/DDK-tagged full-length human MEKK2 protein (hMEKK2-Myc/DDK; +), using MEKK2 Antibody. | |
Immunoprecipitation of MEKK2 from HeLa cell extracts. Lane 1 is 10% input, lane 2 is immunoprecipitation with Normal Rabbit IgG #2729, and lane 3 is immunoprecipitation with MEKK2 Antibody. Western blot analysis was performed using MEKK2 Antibody. |
