M-CSF Receptor Antibody
货号：
3152S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3152S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | M-CSF Receptor Antibody detects endogenous levels of M-CSF receptor. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Macrophage-colony stimulating factor (M-CSF, CSF-1) receptor is an integral membrane tyrosine kinase encoded by the c-fms proto-oncogene. M-CSF receptor is expressed in monocytes (macrophages and their progenitors) and drives growth and development of this blood cell lineage. (1-3). Binding of M-CSF to its receptor induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues used as docking sites for SH2-containing signaling proteins (4). There are at least five major tyrosine autophosphorylation sites. Tyr723 (Tyr721 in mouse) is located in the kinase insert (KI) region. Phosphorylated Tyr723 binds the p85 subunit of PI3 kinase as well as PLC-γ 2 (5). Phosphorylation of Tyr809 provides a docking site for Shc (5). Overactivation of this receptor can lead to a malignant phenotype in various cell systems (6). The activated M-CSF receptor has been shown to be a predictor of poor outcome in advanced epithelial ovarian carcinoma (7) and breast cancer (8). |
| 存放说明 | -20C |
| 计算分子量 | 52 cytoplasmic domain. 140 precursor. 175 M-CSF Receptor. |
参考图片Western blot analysis of extracts from GDM-1 cells, untreated or λ phosphatase-treated, using Phospho-M-CSF Receptor (Tyr723) Antibody #3151 (upper) or M-CSF Receptor Antibody (lower).用抗磷酸化M-CSF 受体(Tyr723)的抗体（上）或抗M-CSF 受体的抗体（下）对经过或未经λ磷酸酶处理的GDM-1细胞的提取物进行免疫印迹检测。 |
