MBTPS2 Antibody
货号：
2157S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 2157S |
| 反应种属 | Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | MBTPS2 Antibody detects endogenous levels of total MBTPS2 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Membrane-bound transcription factor protease site 2 (MBTPS2), also known as site-2 protease (S2P), is a zinc metalloprotease in the Golgi membrane (1,2,3). It regulates cholesterol metabolism (1,2) and unfolded protein response (UPR) (3,4). When cells are deprived of cholesterol, sterol regulatory element-binding proteins (SREBPs) move from the endoplasmic reticulum (ER) to the Golgi apparatus and are cleaved by site-1 protease (S1P) (5,6) and site-2 protease (1,6) sequentially to release the active amino-terminal domains. These amino-terminal domains of SREBPs then translocate into the nucleus to induce expression of genes for cholesterol biosynthesis. During UPR, activating transcription factor 6 (ATF6) transports from ER to Golgi apparatus and is cleaved by S1P and S2P to release a cytosolic fragment. This cytosolic fragment relocates to the nucleus and activates the UPR gene expression (7). |
| 存放说明 | -20C |
| 计算分子量 | 57 |
参考图片Western blot analysis of extracts from Neuro2A and PC-12 cells, using MBTPS2 Antibody. 对Neuro2A和PC-12细胞裂解液使用MBTPS2 Antibody进行Western blot分析。 |
