MARK2 Antibody
货号：
9118S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 9118S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | MARK2 Antibody detects endogenous levels of total MARK2 protein. No cross reactivity is observed with other MARK family members. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Microtubule associated proteins regulate the stability of microtubules and control processes such as cell polarity/differentiation, neurite outgrowth, cell division and organelle trafficking (1). The MARK (MAP/microtubule affinity-regulating kinases) family (MARK1-4) of serine/threonine kinases was identified based on their ability to phosphorylate microtubule-associated proteins (MAPs) including tau, MAP2 and MAP4 (2-6). MARK proteins phosphorylate MAPs within their microtubule binding domains, causing dissociation of MAPs from microtubules and increased microtubule dynamics (2-4). In the case of tau, phosphorylation has been hypothesized to contribute to the formation of neurofibrillary tangles observed in Alzheimers disease. Overexpression of MARK leads to hyperphosphorylation of MAPs, morphological changes and cell death (4). The tumor suppressor kinase LKB1 phosphorylates MARK and the closely related AMP-kinases within their T-loops, leading to increased activity (7). |
| 存放说明 | -20C |
| 计算分子量 | 78, 82 |
参考图片Western blot analysis of extracts from various cell lines using MARK2 Antibody.使用MARK2 Antibody，免疫印迹（Western Blot）分析不同细胞种MARK2蛋白水平。 |
