Lyn Antibody
货号：
2732S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 2732S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | Lyn Antibody detects endogenous levels of the 56 kDa isoform of Lyn. It does not recognize the 53 kDa Lyn isoform. |
| 使用方法 | WB(1:1000)
IP (1:50) |
性能| 供应商 | CST |
| 背景 | Lyn, one of the Src family members, is predominantly expressed in hematopoietic cells (1). Two tyrosine residues have been reported to play a crucial role in the regulation of protein tyrosine kinases of the Src family. Autophosphorylation of Tyr396 (equivalent to Tyr416 of Src), located in the catalytic domain, correlates with enzyme activation. Csk-mediated phosphorylation of the carboxy-terminal Tyr507 (equivalent to Tyr527 of Src) inactivates the kinase. Tyrosine phosphorylation and activation of Lyn occurs upon association with cell surface receptors such as the B cell Ag receptor (BCR) and CD40 (2-4). Studies using knockout mice have shown that the net effect of Lyn deficiency is to render B cells hypersensitive to BCR stimulation (5-7), suggesting that the most critical role for Lyn in vivo is in the down-regulation of B cell responses. Lyn is also involved in controlling the migration and development of specific B cell populations (8). |
| 存放说明 | -20C |
| 计算分子量 | 56 |
参考图片Western blot analysis of extracts from Ramos cells treated with anti-IgM antibody (12 µg/ml for 2 minutes) or untreated, using Lyn Antibody.Western免疫印迹。用Lyn Antibody研究经anti-IgM antibody (12 µg/ml ，2 min)处理的和未经处理的Ramos细胞的细胞提取液。 |
