LIMD1 Antibody
货号：
13245S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 13245S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | LIMD1 Antibody recognizes endogenous levels of total LIMD1 protein. This antibody cross-reacts with a protein of unknown origin at ~45 kDa. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | LIM domain-containing protein 1 (LIMD1) is a putative tumor suppressor and adapter/scaffold protein that belongs to the Ajuba family of LIM domain containing proteins. LIM domain containing proteins mediate protein-protein interactions and typically contain a pair of distinct zinc finger domains (1). Research studies indicate that LIMD1 is involved in numerous cellular processes, including inhibition of E2F mediated transcription (2) and negative regulation of the Hippo pathway through influence on YAP phosphorylation state (3,4). Additional studies identify LIMD1 as a hypoxia regulator as it recruits the Von Hippel-Lindau (VHL) protein and the hydroxylase PHD1 to a protein complex that promotes initiation of HIF-1α ubiquitination and degradation (5). Research evidence supporting the role of LIMD1 as a tumor suppressor includes the down regulation of the protein in 80% of lung cancers (6), loss of LIMD1 expression in head and neck cancers (7), and altered subcellular localization in cases of breast cancer (8). |
| 存放说明 | -20C |
| 计算分子量 | 72 |
参考图片Western blot analysis of extracts from U-2 OS and MCF7 cells using LIMD1 Antibody. 使用LIMD1抗体对U-2OS和MCF7细胞提取物进行western blot分析。 |
