LCP1 Antibody
货号：
5350S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 5350S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | LCP1 Antibody detects endogenous levels of total LCP1 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Highly conserved and widely expressed plastin proteins comprise a subset of actin-binding proteins that include proteins that promote actin bundling. Three plastins exhibiting differential expression are found in mammals and include L-plastin, T-plastin and I-plastin. T-plastin (plastin-3) is found in cells of most solid tissues while I-plastin (plastin-1) is expressed specifically in kidney, colon and small intestine (1-3). L-plastin (plastin-2) or LCP1 (lymphocyte cytosolic protein 1) is mainly expressed in hematopoietic cells and nonhematopoietic tumors, including increased expression correlated with metastatic progression in colon cancer cell lines (4). Overexpression of LCP1 in premetastatic cancer cell lines induces invasion and loss of E-cadherin expression, which is characteristic of metastatic cancer cell lines (5). LCP1 becomes phosphorylated at Ser5 upon stimulation through the T-cell receptor/co-receptor complex (TCR/CD3) in association with the CD2 cell adhesion molecule or the CD28 receptor (6). Phosphorylation at Ser5 increases LCP1 ability to bind F-actin and increase cell motility (7,8). |
| 存放说明 | -20C |
| 计算分子量 | 70 |
参考图片Western blot analysis of extracts from various cell lines using LCP1 Antibody. 使用LCP1 Antibody，免疫印迹（Western Blot）分析不同细胞中LCP1蛋白水平。 |
