LASP1 Antibody
货号：
8636S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 8636S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | LASP1 Antibody detects endogeneous levels of total LASP1 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | LASP1 is a cytoskeletal scaffold protein belonging to the LIM protein subfamily (1,2). LASP1 consists of an N-terminal LIM domain, followed by two nebulin repeats, and a C-terminal SH3 domain (1,3). The nebulin repeats interact with actin, while the SH3 domain interacts with palladin (4,5), suggesting LASP1 functions as an actin-binding protein, possibly in cytoskeletal organization. LASP1 has been shown to localize to focal adhesions, lamellipodia, and membrane ruffles (6-8) and might be involved in membrane migration. Overexpression of LASP1 has been associated with metastatic cancers, such as breast and ovarian cancer (2). In these cases, membrane, cytoplasmic, and nuclear localization of LASP1 in the tumor cell has been reported, suggesting LASP1 involvement in membrane and nuclear signaling (9,10). |
| 存放说明 | -20C |
| 计算分子量 | 38 |
参考图片Western blot analysis of extracts from various cell lines using LASP1 Antibody.使用LASP1抗体对多种细胞提取物进行western blot分析。 |
