LARP1 Antibody
货号：
14763S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 14763S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | La-related protein 1 (LARP1) is a ubiquitously expressed RNA binding protein that promotes both global and specific mRNA translation in cells (1). LARP1 belongs to the La-related protein family and contains two RNA binding domains, a La motif (LAM), and a neighboring RNA recognition motif-like (RRM-L) domain (1). Research studies indicate that LARP1 acts downstream of mTORC1 to facilitate cell proliferation and growth by promoting global mRNA translation and translation of mRNAs containing a 5Terminal Oligo-Pyrimidine (5TOP) motif, which code for translational machinery components (2,3). At the molecular level, LARP1 associates with 5TOP mRNAs and multiple translation machinery components to positively regulate translation (2,4). Additional studies show that LARP1 expression is upregulated in hepatocellular carcinoma (HCC) patients and that high LARP1 expression in HCC negatively correlates with survival rate (5). |
| 存放说明 | -20C |
| 计算分子量 | 150 |
参考图片Western blot analysis of extracts from various cell lines using LARP1 Antibody. |
Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with a construct expressing Myc/DDK-tagged full-length human LARP1 protein (hLARP1-Myc/DDK; +), using LARP1 Antibody (upper) and DYKDDDDK Tag Antibody #2368 (lower). |
