| 货号 | 3089S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | IRS-2 (L1326) Antibody detects endogenous levels of total IRS-2 protein. It does not cross-react with IRS-1. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 背景 | Insulin Receptor Substrate 2 (IRS-2) is one of the major substrates of the insulin receptor kinase (1). In vertebrates, IRS-2 functions as a scaffolding protein to coordinate separate branches of the Insulin/IGF-signaling cascades (2). IRS-2 is essential for normal nutrient homeostasis because it mediates both peripheral insulin action and the effect of IGF-1 on B-cell growth. Mice lacking IRS-2 fail to maintain sufficient compensatory insulin secretion and develop diabetes as young adults (3). |
| 存放说明 | -20C |
| 计算分子量 | 185 |
Western blot analysis of H-4-II-E and HeLa cells using IRS-2 (L1326) Antibody. 对H-4-II-E和HeLa细胞裂解液使用IRS-2 (L1326)抗体进行Western blot分析。 |
