IQGAP1 Antibody
货号：
2293S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 2293S |
| 反应种属 | Human/Mouse/Rat/Hamster/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | IQGAP1 Antibody detects endogenous levels of total IQGAP1 protein. The antibody may cross-react with a 35kDa protein of unknown origin. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | IQGAPs are scaffold proteins involved in mediating cytoskeletal function. They contain multiple protein interaction domains and bind to a growing number of molecules including actin, myosin light chain, calmodulin, E-cadherin and β-catenin (reviewed in 1). Through their GAP-related domains, they bind the small GTPases Rac1 and cdc42. IQGAPs lack GAP activity, however, and regulate small GTPases by stabilizing their GTP-bound (active) forms (2,3). The ubiquitously expressed IQGAP1 is 62% identical to IQGAP2, which is expressed primarily in liver (3). IQGAP1 has been found to interact with APC (4) and the CLIP170 complex (5) in response to small GTPases, in both cases promoting cell polarization and migration. |
| 存放说明 | -20C |
| 计算分子量 | 195 |
参考图片Western blot analysis of extracts from various cell types, using IQGAP1 Antibody. 使用IQGAP1 Antibody，免疫印迹（Western Blot）分析不同细胞中IQGAP1蛋白水平。 |
