Integrin β4 Antibody
货号：
4707S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4707S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Integrin β4 Antibody detects endogenous levels of total integrin β4 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival (1,2). The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities (3). Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with extracellular environment (inside-out signaling) (1,2).
Integrin β4 pairs with integrin α6 on the cell surface membrane to form the integrin α6β4 heterodimer, an important laminin receptor that is essential for hemidesmosome formation and the support of stable adhesions between basal epithelial cells and the basement membrane (4,5). Integrin β4 is an important component in several growth factor induced signaling pathways that are involved in tumorigenesis and invasive cell growth (6,7). |
| 存放说明 | -20C |
| 计算分子量 | 210 |
参考图片Western blot analysis of extracts from various cell types using Integrin β4 Antibody.使用整合素β4抗体对多种细胞提取物进行western blot分析。 |
