Integrin β3 Antibody
货号：
4702S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4702S |
| 反应种属 | Human/Mouse/Rat/Monkey/Bovine |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Integrin beta3 Antibody detects endogenous levels of total integrin beta3. This antibody does not cross-react with other integrin isoforms. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Integrins are heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival (1,2). The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlaping ligand specificities (3). Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling) (1,2). αIIβ3 and αVβ3 are the two β3 containing integrins which are prominently expressed in hematopoietic cells and angiogenic endothelic cells and perform adhesive functions in hemostasis, wound healing and angiogenesis (1,4). Tyr773 and Tyr785 (usually referred to as Tyr747 and Tyr759 based on the chicken sequence) are phosphorylated upon ligand binding (5). Phosphorylation of these tyrosine residues is required for certain ligand-induced signaling (6). Thr779 (corresponding to Thr753 of the chicken sequence) of integrin β3 in the platelet specific αIIβ3 is phosphorylated by PKD and/or Akt, which may modulate integrin association with other signaling molecules (7). |
| 存放说明 | -20C |
| 计算分子量 | 97, 110, 130 |
参考图片Western blot analysis of extracts from HUVEC, BAEC, FDCP1, RLME, Raw and HeLa cells using Integrin beta3 Antibody.使用整合素 beta3 抗体对HUVEC, BAEC, FDCP1, RLME, Raw 和HeLa 细胞提取物进行westernblot分析。 |
