Integrin β1 Antibody
货号：
4706S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4706S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Integrin β1 Antibody detects endogenous levels of total integrin β1 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival (1,2). The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlaping ligand specificities (3). Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with extracellular environment (inside-out signaling) (1,2).
The β1 subfamily includes 12 distinct intergrin proteins that bind to different extracellular matrix molecules (4). Control of extracellular integrin binding influences cell adhesion and migration, while intracellular signaling messages relayed by the β1 cytoplasmic tail helps to regulate cell proliferation, cytoskeletal reorganization and gene expression (4). β1 integrin is implicated in various activities including embryonic development, blood vessel, skin, bone and muscle formation, as well as tumor metastasis and angiogenesis (4,5). |
| 存放说明 | -20C |
| 计算分子量 | 115, 135 |
参考图片Western blot analysis of extracts from various cell types using Integrin β1 Antibody.使用Integrin β1抗体对多种细胞提取物进行western blot分析。 |
