Integrin αV Antibody
货号：
4711S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4711S |
| 反应种属 | Human/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | Integrin αV Antibodies detects endogenous levels of total integrin αV protein. |
| 使用方法 | WB(1:1000)
IP (1:50) |
性能| 供应商 | CST |
| 背景 | Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival (1,2). The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlaping ligand specificities (3). Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with extracellular environment (inside-out signaling) (1,2).
Several αV subfamily members, including αVβ3, αVβ5, αVβ1, are highly expressed in active endothelial cells and cancer cells (3-6) where they play a critical role in angiogenesis and tumor metastasis (7-9). Therefore, interest has focused on αV integrin as a key therapeutic target in the treatment of cancer (10-12). |
| 存放说明 | -20C |
| 计算分子量 | 135, 140 |
参考图片Western blot analysis of extracts from A549 and C6 cells using Integrin αV Antibody.使用整合素αV 抗体对A549 和C6细胞提取物进行western blot分析。 |
