IL-2Rβ Antibody
货号：
4198S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4198S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | IL-2Rβ Antibody detects transfected levels of total IL-2Rβ protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | IL-2 is a T cell stimulatory cytokine best known for inducing T cell proliferation and NK cell proliferation and activation (1,2). IL-2 also promotes peripheral development of Treg cells (3,4). Conversely, IL-2 is involved in activation induced cell death (AICD) that is observed post T cell expansion by increasing levels of Fas on CD4+ T cells (5). The effects of IL-2 are mediated through a trimeric receptor complex consisting of IL-2Rα, IL-2Rβ and the common gamma chain, γc (1,2). IL-2Rα binds exclusively to IL-2 with low affinity and increases binding affinity of the whole receptor complex including IL-2Rβ and γc subunits. IL-15 also binds to IL-2Rβ (1,2). The common γc is used by other cytokines including IL-4, IL-7, IL-9, IL-15, and IL-21 (1,2). Binding of IL-2 initiates signaling cascades involving Jak1, Jak3, Stat5 and the PI3K/Akt pathways (1,2). |
| 存放说明 | -20C |
| 计算分子量 | 60-70 |
参考图片Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with a human IL-2Rβ construct (+), using IL-2Rβ Antibody.Western免疫印迹。用 IL-2Rβ Antibody研究对照转染(-)和转染了人 IL-2Rβ质粒(+)的293T细胞的细胞提取液。 |
